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"The study of vitamin D administration effect on CRP and Interleukin-6 as prognostic biomarkers of ventilator associated pneumonia"
"Excerpt: Interestingly, the mortality rate of patients that treated with vitamin D (5/24) was significantly lower (p=0.04) than that of the placebo group (11/22)."Apparently not interesting enough for proper RCTs with D to be done by now, 9 months into this disease.
"Two things are infinite: the universe and human stupidity; and I'm not sure about the universe." Alfred E. Neuman
Edits: 08/18/20Follow Ups:
Q: Who funds and runs most clinical trials?
A: Big Pharma
...and why not? Who do YOU think should pay for them? Big Ag pays for most of the studies on agricultural chemicals, too.
The studies are required for government regulatory approval, and the studies must be conducted in accordance with testing protocols established by said regulatory agencies. Who else (besides the potential beneficiaries) should be spending years/decades and hundreds of millions (often more than a billion) dollars on research and development, and the conduct of REQUIRED studies?
There are a lot of idiots out there that somehow feel that all of the studies conducted/funded by "Big Pharma" and "Big Ag" are inherently biased/tainted/flawed simply because they are paid-for by those groups that can potentially profit from them. The testing REQUIREMENTS are specified in the Code of Federal Regulations, and further clarified in the Federal Register publications. ANYONE with a few spare billions can sponsor/conduct studies in accordance with these requirements and submit data to the relevant regulatory agency.
So, the title is correct--"apparently not interesting enough"--to justify the tremendous expenditure necessary to gain regulatory approval for use as a registered pharmaceutical.
"No tears to cry. No feelings left. This species has amused itself to death..."--Roger Waters~Amused to Death, 1992
"So, the title is correct--"apparently not interesting enough"--to justify the tremendous expenditure necessary to gain regulatory approval for use as a registered pharmaceutical."
My point, which apparently, in hindsight, I should have made clearer, was that Big Pharma would have little interest in providing funding for proper RCTs for vitamin D, a drug which is already a registered pharmaceutical. There's nothing in it for them.In this case, researchers would be better off pursuing funding from billionaires like Bill Gates or his foundation or the like.
Of course, funding for RCTs could also come from the National Institutes of Health, the Department of Defense, or the Department of Veteran's Affairs.
Edits: 08/19/20
...vitamin D, and the multitude of other "supplements" available are NOT REGISTERED PHARMACEUTICALS. They are REQUIRED BY LAW to be labeled with a DISCLAIMER--"This product is not intended to diagnose, treat, cure, or prevent any disease."
Spend the time/money, do the proper research (in accordance with approved testing protocols), and submit the data for both safety and efficacy. Supplements are just another way to "short-cut" the system--that's why they are cheap--compared to "real" pharmaceuticals. They should just say "take at your own risk".
I can whip up a batch of "snake oil" made from horseshit and lawn clippings and sell it as a "supplement"--as long as it doesn't immediately harm/kill a bunch of people. Even then, it becomes a civil "wrongful death" suit--not a criminal offense, unless it can be proven that I KNOWINGLY poisoned the general public. The supplement industry/market thrives on unsubstantiated claims, and hides behind the disclosure statement I quoted above. Credibility costs money--period--and no one is willing to pay for it.
"No tears to cry. No feelings left. This species has amused itself to death..."--Roger Waters~Amused to Death, 1992
"Just to clarify vitamin D, and the multitude of other "supplements" available are NOT REGISTERED PHARMACEUTICALS. They are REQUIRED BY LAW to be labeled with a DISCLAIMER--"This product is not intended to diagnose, treat, cure, or prevent any disease." "
To further clarify and set the record straight:Yes, vitamin D is a supplement.
Vitamin D is also an FDA approved drug.
When prescribed and used in a prescription dose or in a combination medication (with a prescription medication), it is an FDA approved drug. In addition, active metabolites of vitamin D, vitamin D analogues as well as some vitamin D dosage forms are FDA approved prescription drugs.
Regarding the rest of your comments: Again, in this case, we are not talking about vitamin D as a "supplement", per se; we are talking about vitamin D as a medicament. Additionally, I'm sure that in any RCT, at the minimum, USP Verified (FDA regulated) vitamin D would be used.
Edits: 08/26/20
It costs a LOT to bring a drug from lab to pharmacy.
Studies and testing takes years.
The total government expenditure for research has tended to fall.....
Too much is never enough
It cost nothing to bring D ( and magnesium) to market and giving d to sick people in a study is a relatively easy study to set up.
"Two things are infinite: the universe and human stupidity; and I'm not sure about the universe." Alfred E. Neuman
I don't know how it happens, but an RDA must be arrived at. And some might have bad effects at huge dose levels. Linus Pauling was the Vitamin C guru. He eventually took 20 grams daily. Maybe more? I take a 1.5 grams, which is still way above RDA.
I really don't know how much it costs to bring a vitamin to market. Than purity and dosage must be controlled and verified. Certainly NOT as $$$ as an original compound but still not a trivial sum.
Studies are another matter. Again, you need a qualified test pool, not just a bunch of random persons. You need to organize a double blind study which takes both money AND time. Again, I'd say probably not as bad as a new drug, but again also not 'trivial'.
Bringing to market and the supportive studies are TWO different things.
Too much is never enough
pg,about 793k dead and the world in economic turmoil with trillions lost and no end in sight and you are telling me that it's a problem to study D. You've got to be kidding. There are already supposedly multiple studies going on but I don't know why they have produced so few results so far and the quality is or may be low. Here is a list of , or that includes some interventional studies. I reiterate that there is something wrong with this picture. This is sick, twisted and tragic.The comment on these studies are from the proprietor of vitamindwiki, I would assume.Intervention Trial Summary Table
COVID-19 RCTs
"Two things are infinite: the universe and human stupidity; and I'm not sure about the universe." Alfred E. Neuman
Edits: 08/21/20
don't be angry with ME. I'm not sandbagging the studies.
Drug companies don't make nearly as much on vitamins and such as they do on ORIGINAL drugs which are a cash cow and used to fund the NEXT round of investigations and studies.
So, I guess, Yes, it wouldnt' surprise me that studies of 'easy' stuff to help were being sidelined in the name of corporate greed and profiteering.
Too much is never enough
Well pg, you seemed to be making a case that the studies would be excessively difficult and expensive. This last post of yours appears that we may now be on the same page. If you go to PUBMED the new version now makes it easy to get RCTs where as the old version either did not or I could not find how to do it. If you type in Vitamin D and get the search results you can then filter for RCTs and clinical studies. There are 4015 hits for D and RCTs. Tons of research on D in the past and hopefully soon some of the ones going on now will bare fruit soon. Maybe someone can find a study that taking 100000000000000000000000000000000000000000000 IU of D will kill humans instantly or worse, turn them into into audiophiles.
"Two things are infinite: the universe and human stupidity; and I'm not sure about the universe." Alfred E. Neuman
The trick here is to apply the rule espoused by Deep Throat. That is? 'Follow The Money'.
And never used the word excessive in describing studies for what are essentially vitamins and minerals. The will cost a bunch when directed AT A SPECIFIC Disease or condition. All the prefiltering which must go on and the rest of it.
You don't just start handing out pills. The proper study is of course, double blind.
CDC and FDA must work together to get to the truth of the veracity of some of the claims made about certain OverTheCounter stuff.
I take 'D' daily....and Calcium and have added 'C'. Calcium Citrate is the way I go since it the body uses it better than ground up sea shells or whatever....
Too much is never enough
I suggest you examine how much and how appropriate your calcium supplementation is. It's a particularly tricky subject, IMO.
"Two things are infinite: the universe and human stupidity; and I'm not sure about the universe." Alfred E. Neuman
Bottle suggests 2 pills daily as a 'dose'.
I take a 3rd......
I take 1x 3 times daily.
Too much is never enough
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